Michael Karin Selected Research

Infections

9/2014	IKKα negatively regulates ASC-dependent inflammasome activation.
3/2013	I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection.
1/2012	The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity.
9/2010	Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.
3/2010	NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia.
3/2010	Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia.
1/2009	Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis.
6/2008	An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation.
6/2008	NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.
3/2007	Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.

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Michael Karin Research Topics

Disease

111	Inflammation (Inflammations) 05/2022 - 03/2002
109	Neoplasms (Cancer) 04/2022 - 04/2002
43	Carcinogenesis 05/2022 - 04/2003
17	Liver Neoplasms (Liver Cancer) 03/2021 - 07/2007
17	Infections 09/2014 - 03/2002
16	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 03/2009
15	Obesity 12/2021 - 11/2002
14	Neoplasm Metastasis (Metastasis) 01/2021 - 09/2004
14	Necrosis 07/2014 - 06/2005
11	Fibrosis (Cirrhosis) 01/2021 - 12/2005
10	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 11/2012
10	Insulin Resistance 11/2016 - 11/2002
8	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 04/2007
7	Breast Neoplasms (Breast Cancer) 09/2014 - 04/2003
7	Carcinoma (Carcinomatosis) 03/2012 - 04/2003
6	Liver Diseases (Liver Disease) 12/2021 - 01/2016
6	Type 2 Diabetes Mellitus (MODY) 12/2021 - 11/2002
6	Autoimmune Diseases (Autoimmune Disease) 12/2016 - 01/2010
5	Hypoxia (Hypoxemia) 12/2019 - 06/2008
5	Arthritis (Polyarthritis) 09/2012 - 03/2002
4	Fatty Liver 12/2021 - 03/2016
4	Alcoholic Fatty Liver 03/2021 - 03/2016
4	Non-alcoholic Fatty Liver Disease 03/2021 - 11/2017
4	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021 - 01/2013
4	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2020 - 01/2007
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2020 - 09/2008
3	Adenocarcinoma 01/2021 - 03/2010
3	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2020 - 03/2016
3	Shock 01/2018 - 02/2006
3	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/2017 - 08/2012
3	Lung Neoplasms (Lung Cancer) 01/2016 - 01/2009
3	Melanoma (Melanoma, Malignant) 12/2014 - 07/2010
3	Bacterial Infections (Bacterial Infection) 01/2012 - 09/2007
3	Anthrax 06/2008 - 03/2004
2	Adenocarcinoma of Lung 01/2022 - 01/2008
2	Leukemia 01/2020 - 06/2011
2	Pancreatitis 01/2019 - 05/2010
2	Chronic Disease (Chronic Diseases) 01/2018 - 02/2006

Drug/Important Bio-Agent (IBA)

57	NF-kappa B (NF-kB)IBA 05/2022 - 04/2002
44	CytokinesIBA 05/2022 - 11/2002
35	Phosphotransferases (Kinase)IBA 01/2022 - 11/2002
27	Transcription Factors (Transcription Factor)IBA 05/2022 - 12/2002
22	I-kappa B KinaseIBA 03/2013 - 05/2003
21	Proteins (Proteins, Gene)FDA Link 12/2021 - 12/2002
18	Interleukin-6 (Interleukin 6)IBA 12/2014 - 06/2005
12	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 09/2004
11	AntigensIBA 01/2022 - 04/2006
10	CarcinogensIBA 01/2019 - 10/2007
9	Interleukin-17 (Interleukin 17)IBA 01/2020 - 03/2007
7	InflammasomesIBA 05/2022 - 09/2014
7	AntioxidantsIBA 01/2020 - 03/2005
7	Insulin (Novolin)FDA Link 01/2020 - 11/2002
7	Mechanistic Target of Rapamycin Complex 1IBA 01/2016 - 06/2010
6	Glucose (Dextrose)FDA LinkGeneric 12/2021 - 07/2006
6	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2020 - 07/2004
6	InterleukinsIBA 03/2015 - 06/2008
5	Fatty Acids (Saturated Fatty Acids)IBA 10/2020 - 10/2006
5	Protein Kinases (Protein Kinase)IBA 01/2020 - 01/2005
5	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 01/2019 - 03/2009
5	Pharmaceutical PreparationsIBA 01/2018 - 01/2005
5	Lymphotoxin-alpha (Lymphotoxin)IBA 05/2015 - 10/2009
5	p38 Mitogen-Activated Protein KinasesIBA 12/2014 - 10/2002
4	ChemokinesIBA 05/2022 - 08/2009
4	LigandsIBA 01/2021 - 02/2006
4	CateninsIBA 01/2018 - 08/2012
4	SestrinsIBA 01/2016 - 06/2010
4	LipopolysaccharidesIBA 10/2013 - 09/2004
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2013 - 07/2006
4	Toll-Like Receptors (Toll-Like Receptor)IBA 06/2011 - 01/2009
3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 04/2003
3	CholesterolIBA 03/2021 - 01/2020
3	Immune Checkpoint InhibitorsIBA 01/2021 - 01/2020
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020 - 08/2004
3	Interleukin-10 (Interleukin 10)IBA 11/2017 - 01/2012
3	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2016 - 01/2010
3	Interleukin-23 (Interleukin 23)IBA 07/2015 - 11/2012
3	EnzymesIBA 09/2014 - 02/2005
3	MicroRNAs (MicroRNA)IBA 04/2014 - 12/2011
3	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 09/2012 - 02/2009
3	JNK Mitogen-Activated Protein KinasesIBA 09/2011 - 03/2002
3	B-Cell Activating FactorIBA 11/2010 - 09/2006
3	Protein Isoforms (Isoforms)IBA 01/2009 - 03/2002
2	Ethanol (Ethyl Alcohol)IBA 12/2021 - 03/2016
2	FructoseIBA 12/2021 - 10/2020
2	Collagenases (Collagenase)FDA Link 01/2021 - 01/2013
2	CollagenIBA 01/2021 - 12/2005
2	Metformin (Glucophage)FDA LinkGeneric 01/2021 - 08/2014
2	Bile Acids and Salts (Bile Acids)IBA 01/2021 - 03/2007
2	Peptides (Polypeptides)IBA 01/2021 - 06/2011
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2021 - 05/2015
2	Imatinib Mesylate (Gleevec)FDA Link 01/2020 - 06/2011
2	Interleukin-17 ReceptorsIBA 01/2020 - 12/2014
2	ElementsIBA 12/2019 - 11/2016
2	Tyrosine (L-Tyrosine)FDA Link 01/2018 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 11/2017
2	BilirubinIBA 01/2017 - 01/2012

Therapy/Procedure

38	Therapeutics 01/2022 - 11/2002
10	Immunotherapy 01/2022 - 01/2015
6	Drug Therapy (Chemotherapy) 01/2021 - 01/2009
3	Castration 10/2014 - 03/2010